Now we are waiting for the verdict: whether its an infection in his bladder or stones. I've tried Gatorade and Ginger ale but he only drank a little. She was ok for awhile, then she had a seizure and started throwing up all over the house. Simparica Trio should be used with caution in dogs with a history of seizures. 10 days after taking Simparica, she started having muscle tremors. Saving money sounds great, right? I hope this drug has not caused permanent damage. Since she is young, the vet started us with Keppra. So the next day was Saturday , me & my husband got up early . I am worried! Glad i held off on the free sample i was given! He started having skin issues that the vet said were allergic reactions probably due to environmental things. So your dog got better? I had a trainer come in the day of, and he was with me the all day, NOTHING a happened for him to be in pain! All Rights Reserved. This was the first time she was given this drug and will be the last. My personal dog has had no issues at all, and she's been on it for nearly two years. Poor baby has had vomiting and diarrhoea ever since. I should have kept with my gut feeling about any of these oral meds. Im done with this drug! March 2016 saw the addition of Simparica, yet another so-called Isoxazoline flea and tick "remedy" and already several dogs have been adversely affected by this new drug. Hello! My husband said that he felt like it would just make his coat shiny. Was not too excited about it, and I really should've declined it. Her poor top underside of her tail has raw skin the hair is completely gone like burnt off from diarrhea. After her first dose she had diarrhea, vomiting and developed a terrible wheezing hacking cough. Charlie took the pill on Monday and could not even walk this morning. I feel like it was a massive overdose. Friday early evening Bellas stool was still soft with structure with the outside color almost black but the inside was tinged with lime green. So if your dog actually has meningitis then that wouldn't be related to having given him Simparico but a separate matter altogether. I'm kicking myself I didn't research this drug. If not, we had some success with symptom management using Prednisone. I am so beyond mad, what can I do to get this out of her system and better yet what can we do to get this product off the market. Almost $4k in medical labs, hospital, ultrasound etc no answers. My 3 other poodles unaffected. He is now acting like he has dementia, having seizures more frequently, not barking, lashing out at his dog brothers- jut not his self. Today the seizure like attack happened even though he is on the steroids. Head down, tail down, will stand in a corner and stare at the wall. After spending the day at the ER Vet where they did bloodwork and several x-rays all coming back normal, they sent her home with Keppra. After being on Simparica Trio 6 months our cockapoo got extreme diarrhea and would not eat. I don't give him much treat eather. I honestly think she had a reaction to the medication. Use a collar or topical if you need to. She seems to have aged five years since T-Day. I keep praying she will recover and I feel so guilty for giving it to her. He has been using Simparica Trio since it came out several years ago, which eliminates the need for an additional monthly heart guard chewable. So here we are on the 2nd dose. Buddy 8 year old male Boxer formerly energetic and playful. My dog is experiencing these same symptoms and had his first accident in yearsss in the house and is drinking water excessively. I hope this comment will save you and your pets from unnecessary trouble. Idk what to do. If so how long did it take? (My first warning sign right there). The Simparica was recommended by the vet. I gave my black lab mix Simparica for the 1st time on 4/1. I have read that Simparica may cause side effects including muscle tremors, diarrhea, lethargy, anorexia, otitis externa, hyperactivity, neurological side effects, seizures, convulsions, anxiety and skin irritation . I am so worried about her! Product Information: Simparica Trio (sarolaner, moxidectin, and pyrantel) Chewables are a safe monthly chewable for dogs that prevents heartworm disease, kills adult fleas and is indicated for the treatment and prevention flea infestations, the treatment and control of tick infestations, and the treatment and control of roundworms and . Pyrantel pamoate is a nematocide (kills some worms) belonging to the tetrahydropyrimidine class. Another call to vet asking for an appt - seems like an an emergency now? It's unique because it kills more types of parasites than any other combination product available to date. He seemed okay with his next dose January 1, so we renewed the prescription, and I gave him the February dose too. Humans can get infected with certain intestinal parasites, and fleas sometimes bite people. I take her everywhere as I'm terrified of it happening and her dying, we were convinced she was dying. If she recovers, cause is the Simparica. My Pomeranian is on a steady decline after taking 1 dose. She seems more anxious now and really attached to hubby. I finally got him to eat some chicken and he threw that up 2 hours later. Then things got progressively worse. His motor skills have been affected and hes been losing weight even though he eats heartily. I would NEVER recommend this medication. Been also very lethargic not wanting to get out of bed. The next day, we took him to his vet and had several tests ran (x-rays, bloodwork, etc.). The day I gave it to him, he was up all night just randomly crying and yelping like he was in pain. She's a Brittany (Spaniel). I dont know. He first started with seizures and losing weight in June after giving him Simparica. This is an eye opener for me! Sarolaner (brand name Simparica) is used to treat and control flea and tick infestations in dogs. I dont know whether its a coincidence or not, but 4 days after second dose of Simparica Trio, my dog ended up at an urgent care with blood in his urine. The only thought in my head was to get home and give it to my puppy who has had few fleas, but many itching problems. Some flea and tick products are, Bravecto (fluralaner) topical solution for cats and dogs, Bravecto Plus (fluralaner and moxidectin) topical solution for cats, Bravecto 1-month (fluralaner) tablets for dogs, Credelio (lotilaner) tablets for dogs and cats, Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs, Revolution Plus (selamectin and sarolaner) topical solutionfor cats. This is so scary. HELP!! Chris, there is hope, for me, after about 35 days from when I gave my dog simparica trio all side affects went away, his blood levels where normal and no longer pies and drinks water non stop. Doesn't anyone here wonder why?, if this is sooo safe to use with mammals, isn't there a human version also available? The issues started within 24 hours of the dose and continue. Hopefully there are many other dogs that are unaffected, and just aren't written about here. gave this to my dog three different times. Simparica Trio covers the most common dog parasites and typically costs less than buying separate products. If there are enough reports they may have to pull it off the market until further safety tests can be done. My lab puppies have been taking Simparica Trio for 2 months. The vets and neurologists say it's not simparica trio - but she was perfectly healthy until that dose was given. They drew blood & took a fecal sample . It is recommended that all pets be tested for existing heartworm infection prior to starting treatment with Simparica Trio. Hi Charlene, can you elaborate on agitated swallowing? Hope all is well. Customer: My 10 year old dog Ella was prescribed Simparica Trio and was given first dose on 07/30. I dont like that my dog looks at me like he doesnt know who I am. I am feeding her foods such as spirulina; b12 and a special healing earth in her dinner. There was no clear diagnosis but it was clearly neurological. She had some itching and a bit lethargic but is eating very well. I don't recommend anyone risk their pet's life just to be a little easier having a pill to take. It has been one week and she has been acting very anxious since. Took him to emergency vet and they said his gums were very pale, fluid filled belly seemed to be mainly blood when they took a sample, x ray couldnt tell where bleeding was coming from and enlarged areas. My other Lab after 5 days started having severe diaherria (black at first, now golden) and now throwing up too. After doing more research on their monthly medication, I will no longer use Simparica Trio nor ever recommend it. After seeing his condition worsen, that night we took him to an after hours urgent care. She had some good days and we were hopeful but ultimately, she steadily declined. How is your dog now? Again our dog had a major seizure in January and we searched for a neurologist ear by. Sold as 1 Month, 3 Month or 6 Month Supply for the following dog weights : 2.8-5.5 lbs, 5.5-11 lbs, 11-22 lbs, 22-44 lbs, 44-88 lbs, 88-132 lbs. But then the first time I increased from 6mg to 12mg (again on advice of the vet) as his weight increased, the tremors got noticably worse and he started stumbling for no reason. Simparica, NexGard, Bravecto & Credelio may not increase the number of seizures, but the risk is real. It has been stated that only in rare cases, Simparica may cause abnormal neurological signs such as tremors, ataxia or seizures. Sarolaner is effective against the following tick species: Moxidectin is an antiparasitic drug in the macrocyclic lactone class. Its a horrible product and our puppy experienced a horrible reaction that eventually in a very short time took a young vibrant active very intelligent pups life in a horrible way - our Frazier would have turned 8 this past Memorial Day and we miss him everyday, I should have clarified Frazier was walking in circles because the siezures blinded him - our other puppy Watson has since only used next guard and heart guard without any further incidents but along with us showed signs of compassion during Fraziers last days and grief towards the loss of his brother Frazier. She is absolutely miserable and we're hoping she makes it. Hi, how much charcoal did you administer? You don't think I'm going to continue with this poison. Our dog has had 2 Seizures this month and we are going to stop using Simparica. I gave my 15 year old dog this medicine. Thanks! Went to a different vet, within minutes he found a large mass on my Poms abdomen. Reading all of these comments I too think it is the drug that has caused his body to be toxic for him. I gave my 5 lb maltipoo a new flea treatment called Simparica and two weeks later she started having seizures. They have increased and worsened over the last 3 months. So sorry! Thank you for giving information on what happened to your dog. Hi Laura, How is you pup doing one after getting off simparica? Mine has tremors once in a while and now I know why! Then suddenly dog has diarrhea and it lasted for several days. Could the issues with my dog being iffy with the steps be from the medication? The cardiologist found no heart condition that would cause this. Your vet should be able to answer any questions related to side effects, precautions, or special care for your dog. Good luck. My best friend's new puppy has had diarrhea for 14 days after taking one dose of Simparica. Simparica can't be used on younger dogs or lactating dogs whereas Revolution can. Vet thought was inner ear infection now thinking otherwise. Once again peed in my office on Saturday. She continued to have seizures even she was on phenobarbital. We gave our 3.5 month old Aussie pup a dose of Simparica today (vet's prescription), and I did not see the warnings about giving it to dogs under 6 months. So sorry to hear, and good for you in recognizing the problem! My chihuahua was given this three weeks back, I actually requested I kept my old treatment but they assured me it was safe and good. In such cases, please visit the veterinarian as soon as possible. This is lethal medication for dogs and should be taken off the market now. Eyes roll back. Im not sure if the simperica is the cause. Then the following week 1 pill every other day . He walked outside peed then tried to come back in the house but his legs gave out . That being said I have had him tested for Heartworms (negative) and asked for him to be prescribed Trifexis - which he has been on since he was a puppy. They were good to deal with. After being ingested by a dog, sarolaner is distributed throughout the body. If your dog or cat experiences any adverse event while using an isoxazoline product, first consult your veterinarian. Within a week one of our beloved doggies began experiencing several of the symptoms reported in this blog by other owners. 98. I tried everything but she just didnt have an appetite for anything. The Simparica chewable is a poor choice for dogs with a history of prior seizures. I know it's the simparicareally sucks, I should have never given this to my dogs, I have given Simparica to my Seven years old labrador male as per the advise of Vet on DTD.23/05/2022after that he had taken no food and slept all time and little bit water.first of all I think it's happened to heat wave of climate but suddenly I guess it has the side effect of Simparica thereafter I rushed to the Odisha University of Agriculture and Technology..after blood testthe vet. I have a person that bought a husky puppy from me March 6 @ 6 weeks old. I hope for all of you that your pets (loved ones) have improved, I know the feeling of total helplessness to help them and all you can do is wait and hope. Shame on you! We tried stopping the simparica. Simparica has possibly shown no severe side effects that may concern the health of dogs. My dog steadily went downhill after I gave her the first dose of simparica. He is disoriented, his head just hangs and he is lifeless. I found a warning from the FDA about the potential for neurologic adverse events in dogs and cats when treated with drugs that are in the isoxazoline class. But now I'm almost convinced that they could have been seizures, and I just pray that they weren't, and pray that he doesn't have to experience anymore troubles. We administered the first dose on Wednesday June 1st to our 9 year old bouvier flanders. Will not be using this treatment again!!! Gave this flea medicine today and by 10 pm toy poodle having siesures every 3-10 seconds. 38 results for "simparica trio for dogs" RESULTS. My vets comment was I would know if his symptoms were related if at time for next dose his symptoms were gone they are gone. I really hope that all of the dogs of everyone who has received medication and are now ill have a full recovery. Our dog has not been given another dose. If fact it specifically states on the product label "Not for use in humans". Hi Laura, just wondering what supplements you gave your pup to help and how long it took for her to get back to herself after simparica. And how do we get the word out to everyone? Zoetis (Simparica, Simparica Trio, Revolution Plus): 888-963-8471; If you prefer to report directly to the FDA, or want additional information about adverse drug experience reporting for animal drugs, see How to Report Animal Drug and Device Side Effects and Product Problems. Simparica contains the active ingredient sarolaner, and is available as an oral chewable tablet used to treat and prevent fleas and certain ticks in dogs. I dont want to have to put my dog down but hes suffering. Took her to her Vet where I was told she had another tremor. The vet recognized immediately that she was in severe neurogical distress. Fortunately for conscientious dog moms and dads, Simparica offers a once-a-month chewable treatment that is FDA-approved and safe for Fido, taking the guesswork out of fighting fleas and ticks. Thanks Michelle! Certain age, breed predispositions. The vet came and picked her up and cut her opened and said and told me she could anything wrong with her so it was either she was poisoned or it was a neurological disorder. He protected our livestock from coyotes for many years and I took good care of him. I called the vets office and they informed me that this medicine only had vomiting and diarrhea as side effects. I'm so sorry. My dog is on a "health care plan" with my vet. It definitely can cross blood brain barrier and cause other neurological issues so it makes sense it could do this too, but clearly they havent done enough research to understand how. So from what I understand, your dog was on this for 6 months and got the serious symptoms after that? Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching . We are beyond sad and livid! The same thing possibly is happening to my 9 month old Boxador. Was hospitalized for 2 1/2 days. 1 dose of this Simperica Trio and he is completely different and cant hold his pee. Simparica trio is a de-worming medication. He is acting very skittish/scared like behavior, wants to just lay down. They have become so bad that she cries and whimpers any time she is laying down. The leaflet inside at least needs to be changed to have the correct information on it. i know this med did this to her , she was on for a year and half , i should never ever have listened to the vet and went with my gut, but again they assured me since she was healthy be very rare she would have side effects smdh and plus been in contract with the makers of this horrible medication they all should be ashamed of themselves!!!!!!!!!!! I have already had a bad experience with "k9 advantix", so I refuse to buy over the counter drugs for my 13 week old Auggie. I have always used topical tx. It didnt even occur to me it could be the drug as my doctor just gave individual pills and I didnt get to read side effects. She's been given this dosage for over a year. Use with caution in dogs with a history of seizures. Has anyones dog stopped having seizures when the medication wore off or is this going to be a permanent issue possibly getting worse? Initially I noticed minor tremors and twitching when he slept or was just relaxing. I never saw a flea because he has a very thick coat. Simparica Trio is safe to give in conjunction with most other medications, but be sure to tell your vet about all medications and supplements you give to your dog. He was a dog you could pick up anytime and he was good as gold. I went and picked her up today and all she does is lay around and drink water, turns her nose up at anything food related. Can my dog still get Lyme disease from a tick that was in him. Hi i have only had my pup for about a week and a half i took him to vet and asked what would be safe to use since my pup is only about 11weeks old and weighs 4pds (prob less today) i gave him this medicine last nite and wish i would have seen this post sooner Now i pray he makes it thru the night. But now I tell everyone just be aware that this product does have the potential to cause neurological harm. 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